Tylosin base
tylosin
CAS: 1401-69-0
Molecular Formula: C46H77NO17
Tylosin base - Names and Identifiers
Tylosin base - Physico-chemical Properties
| Molecular Formula | C46H77NO17 |
| Molar Mass | 916.1 |
| Density | 1.1424 (rough estimate) |
| Melting Point | 135-137°C |
| Boling Point | 796.05°C (rough estimate) |
| Specific Rotation(α) | D25 -46° (c = 2 in methanol) |
| Flash Point | 546.9°C |
| Water Solubility | H2O: soluble 50 mg/mL |
| Vapor Presure | 0mmHg at 25°C |
| pKa | pKa 7.73(H2Ot = 25I = 0.167) (Uncertain) |
| Storage Condition | Sealed in dry,2-8°C |
| Stability | Solutions are stable at pH 4-9 (most stable at pH 7); Below pH 4 tylosin B (desmycosin) is formed as a result of acid hydrolysis; In neutral and alkaline pH – tylosin aldol (TAD) is formed toget |
| Refractive Index | 1.5280 (estimate) |
| MDL | MFCD09881413 |
| Use | Used as an antibacterial |
| In vitro study | Tylosin exerts antibacterial effects by binding to 23S rRNA of the bacterial ribosomal 50S subunit . Tylosin also prevents growth of Gram-negative strains, with MICs of 64 μg/mL, 32 μg/mL, 512 μg/mL and 1 μg/mL for M. haemolytica 11935, P. multocida 4407, E. coli ATCC 25922 and E. coli AS19rlmA I , respectively. |
Tylosin base - Risk and Safety
| Risk Codes | R42/43 - May cause sensitization by inhalation and skin contact. R50 - Very Toxic to aquatic organisms |
| Safety Description | S36 - Wear suitable protective clothing. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S22 - Do not breathe dust. |
| HS Code | 2941906000 |
| Toxicity | Tylosin base and its salts were shown to be of low acute oral toxicity with LD50 values in excess 5000 mg/kg bw in the rat and mouse and greater than 800 mg/kg bw in the dog. |
Tylosin base - Upstream Downstream Industry
| Downstream Products | Cefepime hydrochloride |
Tylosin base - Introduction
Nature:
1. Tylosin is a white to light yellow crystalline powder with a special odor, easily soluble in organic solvents such as methanol, ethanol, chloroform, and insoluble in water.
2. Stable at high temperatures, but prone to decomposition in damp and direct sunlight.
Method:
The production of Tylosin is usually carried out through microbial fermentation, which is produced through the cultivation of actinomycete microorganisms. Firstly, high-quality actinomycete microorganisms are used for fermentation production, followed by extraction and purification to obtain the powder form of Tylosin.
Last Update：2024-06-11 15:30:18
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Spot supply
Product Name: Tylosin Visit Supplier Webpage Request for quotationCAS: 1401-69-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple SpecificationsSpot supply
Product Name: Tylosin Visit Supplier Webpage Request for quotationCAS: 1401-69-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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Downstream Products for Tylosin base